Introduction: The coexistence of synchronic duodenal gastrointestinal\nstromal tumor (GIST) and neuroendocrine tumor in a patient with neurofibromatosis\ntype 1 (NF1) is extremely rare, and only eight cases were described\nin the literature. Clinical Case: This is a rare case of a 38-year-old\nfemale patient with NF1 who developed synchronic GIST and neuroendocrine\ntumor, which were both in the second portion of the duodenum. The\nfirst symptoms were abrupt digestive bleeding and anemia. Upper digestive\nendoscopy revealed two tumors, sizes 2.5 and 3.0 cm, in the second portion of\nduodenum, with biopsies identifying a GIST and a neuroendocrine tumor.\nTherapeutic decision was to proceed to surgical resection, and Whippleâ??s\nprocedure was indicated. Surgical procedure was performed with good outcome.\nCurrently the patient has excellent quality of life and maintains follow\nup for thirty months without recurrence. Discussion: Long-term disease-free\nsurvival and excellent quality of life are reported when these tumors are fully\nresected in this context. However, it is not always easy to access the gastrointestinal\ntract, especially the small intestine, and proceed to the histopathologic diagnosis\nof these tumors. Conclusion: It is important to be aware of the possibility\nof the coexistence of various tumors in the NF1 scenario for adequate\nscreening, staging, and surgical treatment of these patients, as good prognosis\ncan be achieved when such tumors are detected and treated properly.
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